{"id":5329,"date":"2023-03-27T15:22:58","date_gmt":"2023-03-27T13:22:58","guid":{"rendered":"https:\/\/www.jphres.org\/?p=5329"},"modified":"2023-04-02T14:15:13","modified_gmt":"2023-04-02T12:15:13","slug":"prevalence-and-molecular-epidemiology-of-human-papillomavirus-infection-in-italian-women-with-cervical-cytological-abnormalities","status":"publish","type":"page","link":"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/157\/","title":{"rendered":"Prevalence and molecular epidemiology of human papillomavirus infection in Italian women with cervical cytological abnormalities"},"content":{"rendered":"<div class=\"item doi\"><span class=\"value\"><a href=\"https:\/\/doi.org\/10.4081\/jphr.2014.157\">https:\/\/doi.org\/10.4081\/jphr.2014.157<\/a><\/span><\/div>\n<ul class=\"item authors\">\n<li><span class=\"name\"><strong>Angelo Meloni<\/strong><br \/>\n<\/span><span class=\"affiliation\">Section of Hygiene, Department of Public Health, Molecular and Clinical Medicine, Cagliari University, Italy.<\/span><\/li>\n<li><span class=\"name\"><strong>Roberta Pilia<\/strong><br \/>\n<\/span><span class=\"affiliation\">Section of Hygiene, Department of Public Health, Molecular and Clinical Medicine, Cagliari University, Italy.<\/span><\/li>\n<li><span class=\"name\"><strong>Marcello Campagna<\/strong><br \/>\n<\/span><span class=\"affiliation\">Section of Hygiene, Department of Public Health, Molecular and Clinical Medicine, Cagliari University, Italy.<\/span><\/li>\n<li><span class=\"name\"><strong>Antonella Usai<\/strong><br \/>\n<\/span><span class=\"affiliation\">Section of Hygiene, Department of Public Health, Molecular and Clinical Medicine, Cagliari University, Italy.<\/span><\/li>\n<li><span class=\"name\"><strong>Giuseppina Masia<\/strong><br \/>\n<\/span><span class=\"affiliation\">Section of Hygiene, Department of Public Health, Molecular and Clinical Medicine, Cagliari University, Italy.<\/span><\/li>\n<li><span class=\"name\"><strong>Valeria Caredda<\/strong><br \/>\n<\/span><span class=\"affiliation\">Centre for Women Health, Local Health District of Cagliari, Italy.<\/span><\/li>\n<li><span class=\"name\"><strong>Rosa Cristina Coppola<\/strong><br \/>\n<\/span><span class=\"affiliation\">Section of Hygiene, Department of Public Health, Molecular and Clinical Medicine, Cagliari University, Italy.<\/span><\/li>\n<\/ul>\n<p><strong>ABSTRACT<\/strong><\/p>\n<p><em>Background<\/em>. Human papillomavirus (HPV) infection is the most common sexually transmitted infection and high-risk HPV types are a necessary cause for the development of cervical cancer. The present study investigated the HPV-type specific prevalence in 650 women, aged 15-76 years, with cytological abnormalities and the association between HPV infection and cervical disease in a subset of 160 women for whom cytological results for Pap-Test were available, during the period 2008-2011 in Cagliari (Southern Italy).<br \/>\n<em><br \/>\nDesign and Methods<\/em>. HPV-DNA extraction was performed by lysis and digestion with proteinase K and it was typed by using the INNOLiPA HPV Genotyping Assay.<br \/>\n<em><br \/>\nResults<\/em>. Overall the HPV prevalence was 52.6%; high-risk genotypes were found in 68.9% of women and multiple-type infection in 36.1% of HPV-positive women. The commonest types were HPV-52 (23.4%), HPV-53 (15.7%), HPV-16 (15.4%) and HPV-6 (12.4%). Among the women with cytological diagnosis, any-type of HPV DNA was found in 49.4% of the samples and out of these 93.7% were high-risk genotypes. Genotype HPV 53 was the commonest type among women affected by ASCUS lesions (21.4%), genotype 52 in positive L-SIL cases (22.5%), genotype 16 H-SIL (27.3%).<br \/>\n<em><br \/>\nConclusions<\/em>. This study confirmed the high prevalence of HPV infection and high-risk genotypes among women with cervical abnormalities while, unlike previously published data, genotype HPV-52 was the most common type in our series. These data may contribute to increase the knowledge of HPV epidemiology and designing adequate vaccination strategies.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>https:\/\/doi.org\/10.4081\/jphr.2014.157 Angelo Meloni Section of Hygiene, Department of Public Health, Molecular and Clinical Medicine, Cagliari University, Italy. Roberta Pilia Section of Hygiene, Department of Public Health, Molecular and Clinical Medicine, Cagliari University, Italy. Marcello Campagna Section of Hygiene, Department of Public Health, Molecular and Clinical Medicine, Cagliari University, Italy. Antonella Usai Section of Hygiene, Department &#8230; <a title=\"Prevalence and molecular epidemiology of human papillomavirus infection in Italian women with cervical cytological abnormalities\" class=\"read-more\" href=\"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/157\/\" aria-label=\"More on Prevalence and molecular epidemiology of human papillomavirus infection in Italian women with cervical cytological abnormalities\">Read more<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-5329","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Prevalence and molecular epidemiology of human papillomavirus infection in Italian women with cervical cytological abnormalities - Journal of Public Health Research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/157\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Prevalence and molecular epidemiology of human papillomavirus infection in Italian women with cervical cytological abnormalities - Journal of Public Health Research\" \/>\n<meta property=\"og:description\" content=\"https:\/\/doi.org\/10.4081\/jphr.2014.157 Angelo Meloni Section of Hygiene, Department of Public Health, Molecular and Clinical Medicine, Cagliari University, Italy. Roberta Pilia Section of Hygiene, Department of Public Health, Molecular and Clinical Medicine, Cagliari University, Italy. Marcello Campagna Section of Hygiene, Department of Public Health, Molecular and Clinical Medicine, Cagliari University, Italy. Antonella Usai Section of Hygiene, Department ... 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Roberta Pilia Section of Hygiene, Department of Public Health, Molecular and Clinical Medicine, Cagliari University, Italy. Marcello Campagna Section of Hygiene, Department of Public Health, Molecular and Clinical Medicine, Cagliari University, Italy. Antonella Usai Section of Hygiene, Department ... 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