{"id":5219,"date":"2023-03-29T12:54:12","date_gmt":"2023-03-29T10:54:12","guid":{"rendered":"https:\/\/www.jphres.org\/?p=5219"},"modified":"2023-04-02T13:57:13","modified_gmt":"2023-04-02T11:57:13","slug":"impact-of-childhood-and-maternal-vaccination-against-diphtheria-tetanus-and-pertussis-in-colombia","status":"publish","type":"page","link":"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/2588\/","title":{"rendered":"Impact of childhood and maternal vaccination against diphtheria, tetanus, and pertussis in Colombia"},"content":{"rendered":"<div class=\"item doi\"><span class=\"value\"><a href=\"https:\/\/doi.org\/10.4081\/jphr.2021.2588\">https:\/\/doi.org\/10.4081\/jphr.2021.2588<\/a><\/span><\/div>\n<ul class=\"item authors\">\n<li><span class=\"name\"><strong>Mar\u00eda Cristina Hoyos<\/strong><br \/>\n<\/span><span class=\"affiliation\">National School of Public Health &#8220;H\u00e9ctor Abad G\u00f3mez&#8221;, University of Antioquia, Medellin, Antioquia, Colombia.<\/span><span class=\"orcid\"><br \/>\n<a href=\"https:\/\/orcid.org\/0000-0001-9579-2335\" target=\"_blank\" rel=\"noopener\">https:\/\/orcid.org\/0000-0001-9579-2335<\/a><\/span><\/li>\n<li><span class=\"name\"><strong>Doracelly Hincapi\u00e9-Palacio<\/strong><br \/>\n<\/span><span class=\"affiliation\">National School of Public Health &#8220;H\u00e9ctor Abad G\u00f3mez\u201d, University of Antioquia, Medellin, Antioquia, Colombia.<\/span><span class=\"orcid\"><br \/>\n<a href=\"https:\/\/orcid.org\/0000-0002-7476-0411\" target=\"_blank\" rel=\"noopener\">https:\/\/orcid.org\/0000-0002-7476-0411<\/a><\/span><\/li>\n<li><span class=\"name\"><strong>Jesus Ochoa<\/strong><br \/>\n<\/span><span class=\"affiliation\">National School of Public Health &#8220;H\u00e9ctor Abad G\u00f3mez\u201d, University of Antioquia, Medellin, Antioquia, Colombia.<\/span><span class=\"orcid\"><br \/>\n<a href=\"https:\/\/orcid.org\/0000-0002-9233-2330\" target=\"_blank\" rel=\"noopener\">https:\/\/orcid.org\/0000-0002-9233-2330<\/a><\/span><\/li>\n<li><span class=\"name\"><strong>Alba Le\u00f3n<\/strong><br \/>\n<\/span><span class=\"affiliation\">School of Medicine, University of Antioquia, Medellin, Antioquia, Colombia.<\/span><\/li>\n<\/ul>\n<p><strong>ABSTRACT<\/strong><\/p>\n<p><strong>Background:<\/strong>\u00a0In Latin America, there are few studies of the impact of vaccination against diphtheria, tetanus, and pertussis. We estimate the impact of infant and maternal vaccination on the incidence of these diseases in Colombia.<br \/>\n<strong><br \/>\nDesign and methods<\/strong>: an interrupted time series study analyzing the incidence before and after of vaccination with DwPT (1975-2018) and with Tdap in pregnant women (2008-2018). A segmented regression model with negative binomial distribution estimated the change in level and trend of the predicted incidence ratio after vaccination in relation to the incidence if vaccination had not been started (IRR), using a Prais Winsten regression.<br \/>\n<strong><br \/>\nResults:<\/strong>\u00a0The pertussis IRR decreased immediately after the start of childhood vaccination (0.91, p=0.51), but this was only significant (1.01, p&lt;0.001) along with the trend per year, after the start of maternal vaccination (0.98, p&lt;0.001). In the absence of vaccination, the incidence would not have been reduced. Neonatal tetanus had the highest rate of change with significant reduction -1.69 &#8211; CI 95%: -2.91, -0.48). The trend after vaccination was the highest with an annual reduction of 19% (0.81, p=0.001). The change in incidence of diphtheria was significant, although slow (-0.02 &#8211; CI 95%: -0.04, -0.004). The sustained effect in the post-vaccination period was smaller (0.95, p=0.79).<br \/>\n<strong><br \/>\nConclusions:<\/strong>\u00a0Childhood and maternal vaccination markedly reduced the incidence of pertussis and neonatal tetanus. It is necessary to maintain optimal vaccination coverage and surveillance, within an integrated elimination plan, which prevents the resurgence of these diseases.<\/p>\n<p><strong>AUTHOR BIOGRAPHIES<\/strong><\/p>\n<div class=\"sub_item\">\n<div class=\"label\">Doracelly Hincapi\u00e9-Palacio,\u00a0<span class=\"affiliation\">National School of Public Health &#8220;H\u00e9ctor Abad G\u00f3mez\u201d, University of Antioquia, Medellin, Antioquia<\/span><\/div>\n<div class=\"value\">\n<p>Msc; PhD is a professor and researcher in Epidemiology at the National School of Public Health &#8211; University of Antioquia. His research interests are vaccine-preventable diseases, mathematical models and epidemiological surveillance.<\/p>\n<\/div>\n<\/div>\n<div class=\"sub_item\">\n<div class=\"label\">Jesus Ochoa,\u00a0<span class=\"affiliation\">National School of Public Health &#8220;H\u00e9ctor Abad G\u00f3mez\u201d, University of Antioquia, Medellin, Antioquia<\/span><\/div>\n<div class=\"value\">\n<p>Msc; PhD is a professor and researcher in epidemiology at the National School of Public Health &#8211; University of Antioquia. His research interests are vaccine-preventable diseases, hospital infection control and epidemiological surveillance.<\/p>\n<\/div>\n<\/div>\n<div class=\"sub_item\">\n<div class=\"label\">Alba Le\u00f3n ,\u00a0<span class=\"affiliation\">School of Medicine, University of Antioquia, Medellin, Antioquia<\/span><\/div>\n<div class=\"value\">\n<p>Msc in Biostatistics is a professor and researcher in health information systems and epidemiology at the School of Medicine &#8211; University of Antioquia. His research interests are statistical analysis in epidemiology<\/p>\n<p><strong>REFERENCES<\/strong><\/p>\n<p>Dinleyici EC, Borrow R, Safadi MAP, et al. Vaccines and routine immunization strategies during the COVID-19 pandemic. Hum Vaccin Immunother 2021;17:400-7. DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1080\/21645515.2020.1804776\">https:\/\/doi.org\/10.1080\/21645515.2020.1804776<\/a><\/p>\n<p>Mezones-Holguin E, Al-Kassab-Cordova A, Maguina JL, Rodriguez-Morales AJ. 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Available from:\u00a0<a href=\"https:\/\/www.who.int\/publications\/i\/item\/tetanus-vaccines-who-position-paper-february-2017\">https:\/\/www.who.int\/publications\/i\/item\/tetanus-vaccines-who-position-paper-february-2017<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>https:\/\/doi.org\/10.4081\/jphr.2021.2588 Mar\u00eda Cristina Hoyos National School of Public Health &#8220;H\u00e9ctor Abad G\u00f3mez&#8221;, University of Antioquia, Medellin, Antioquia, Colombia. https:\/\/orcid.org\/0000-0001-9579-2335 Doracelly Hincapi\u00e9-Palacio National School of Public Health &#8220;H\u00e9ctor Abad G\u00f3mez\u201d, University of Antioquia, Medellin, Antioquia, Colombia. https:\/\/orcid.org\/0000-0002-7476-0411 Jesus Ochoa National School of Public Health &#8220;H\u00e9ctor Abad G\u00f3mez\u201d, University of Antioquia, Medellin, Antioquia, Colombia. https:\/\/orcid.org\/0000-0002-9233-2330 Alba Le\u00f3n &#8230; <a title=\"Impact of childhood and maternal vaccination against diphtheria, tetanus, and pertussis in Colombia\" class=\"read-more\" href=\"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/2588\/\" aria-label=\"More on Impact of childhood and maternal vaccination against diphtheria, tetanus, and pertussis in Colombia\">Read more<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-5219","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Impact of childhood and maternal vaccination against diphtheria, tetanus, and pertussis in Colombia - Journal of Public Health Research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/2588\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Impact of childhood and maternal vaccination against diphtheria, tetanus, and pertussis in Colombia - Journal of Public Health Research\" \/>\n<meta property=\"og:description\" content=\"https:\/\/doi.org\/10.4081\/jphr.2021.2588 Mar\u00eda Cristina Hoyos National School of Public Health &#8220;H\u00e9ctor Abad G\u00f3mez&#8221;, University of Antioquia, Medellin, Antioquia, Colombia. https:\/\/orcid.org\/0000-0001-9579-2335 Doracelly Hincapi\u00e9-Palacio National School of Public Health &#8220;H\u00e9ctor Abad G\u00f3mez\u201d, University of Antioquia, Medellin, Antioquia, Colombia. https:\/\/orcid.org\/0000-0002-7476-0411 Jesus Ochoa National School of Public Health &#8220;H\u00e9ctor Abad G\u00f3mez\u201d, University of Antioquia, Medellin, Antioquia, Colombia. https:\/\/orcid.org\/0000-0002-9233-2330 Alba Le\u00f3n ... 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