{"id":4912,"date":"2023-03-27T13:35:55","date_gmt":"2023-03-27T11:35:55","guid":{"rendered":"https:\/\/www.jphres.org\/?p=4912"},"modified":"2023-04-02T14:15:52","modified_gmt":"2023-04-02T12:15:52","slug":"a-biotechnological-approach-for-the-development-of-new-antifungal-compounds-to-protect-the-environment-and-the-human-health","status":"publish","type":"page","link":"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/613\/","title":{"rendered":"A biotechnological approach for the development of new antifungal compounds to protect the environment and the human health"},"content":{"rendered":"<div class=\"item doi\"><span class=\"value\"><a href=\"https:\/\/doi.org\/10.4081\/jphr.2015.613\">https:\/\/doi.org\/10.4081\/jphr.2015.613<\/a><\/span><\/div>\n<ul class=\"item authors\">\n<li><span class=\"name\"><strong>Claudia Zani<\/strong><br \/>\nDepartment of Medical and Surgical Specialities, Radiological Sciences and Public Health, University of Brescia, Italy.<\/span><\/li>\n<li><span class=\"name\"><strong>Francesco Maria Restivo<\/strong><br \/>\n<\/span><span class=\"affiliation\">Department of Life Sciences, University of Parma, Italy.<\/span><\/li>\n<li><span class=\"name\"><strong>Mauro Carcelli<\/strong><br \/>\n<\/span><span class=\"affiliation\">Department of Chemistry, University of Parma, Italy.<\/span><\/li>\n<li><span class=\"name\"><strong>Donatella Feretti<\/strong><br \/>\n<\/span><span class=\"affiliation\">Department of Medical and Surgical Specialities, Radiological Sciences and Public Health, University of Brescia, Italy.<\/span><\/li>\n<li><span class=\"name\"><strong>Giorgio Pelosi<\/strong><br \/>\n<\/span><span class=\"affiliation\">Department of Chemistry, University of Parma, Italy.<\/span><\/li>\n<li><span class=\"name\"><strong>Dominga Rogolino<\/strong><br \/>\n<\/span><span class=\"affiliation\">Department of Chemistry, University of Parma, Italy.<\/span><\/li>\n<li><span class=\"name\"><strong>Francesca Degola<\/strong><br \/>\n<\/span><span class=\"affiliation\">Department of Life Sciences, University of Parma, Italy.<\/span><\/li>\n<li><span class=\"name\"><strong>Serena Galati<\/strong><br \/>\n<\/span><span class=\"affiliation\">Department of Life Sciences, University of Parma, Italy.<\/span><\/li>\n<li><span class=\"name\"><strong>Franco Bisceglie<\/strong><br \/>\n<\/span><span class=\"affiliation\">Department of Chemistry, University of Parma, Italy.<\/span><\/li>\n<li><span class=\"name\"><strong>Annamaria Buschini<\/strong><br \/>\n<\/span><span class=\"affiliation\">Department of Life Sciences, University of Parma, Italy.<\/span><\/li>\n<\/ul>\n<div class=\"item abstract\">\n<h3 class=\"label\">ABSTRACT<\/h3>\n<p><em>Background<\/em>. In the Po Valley aflatoxins play a relevant role: the local food economy is heavily based on cereal cultivations for animal feed and human nutrition. Aims of this project are the identification of new compounds that inhibit\u00a0<em>Aspergillus<\/em>\u00a0proliferation, the development of new inhibitors of aflatoxins production, and the set-up a practical screening procedure to identify the most effective and safe compounds.<br \/>\n<em><br \/>\nDesign and Methods.<\/em>\u00a0New compounds will be synthetized with natural origin molecules as ligands and endogenous metal ions to increase their bioavailability for the fungi as metal complexes. A biotechnological high-throughput screening will be set up to identify efficiently the most powerful substances. The newly synthesized compounds with effective antifungal activities, will be evaluated with battery of tests with different end-points to assess the toxic potential risk for environmental and human health.<br \/>\n<em><br \/>\nExpected impact of the study for public health.<\/em>\u00a0The fundamental step in the project will be the synthesis of new compounds and the study of their capability to inhibit aflatoxin biosynthesis. A new, simple, inexpensive and high-throughput method to screen the anti-fungine and anti-mycotoxin activity of the new synthesised compounds will be applied. The evaluation of possible risks for humans due to toxic and genotoxic activities of the molecules will be made with a new approach using different types of cells (bacteria, plants and human cells).<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>https:\/\/doi.org\/10.4081\/jphr.2015.613 Claudia Zani Department of Medical and Surgical Specialities, Radiological Sciences and Public Health, University of Brescia, Italy. Francesco Maria Restivo Department of Life Sciences, University of Parma, Italy. Mauro Carcelli Department of Chemistry, University of Parma, Italy. Donatella Feretti Department of Medical and Surgical Specialities, Radiological Sciences and Public Health, University of Brescia, Italy. &#8230; <a title=\"A biotechnological approach for the development of new antifungal compounds to protect the environment and the human health\" class=\"read-more\" href=\"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/613\/\" aria-label=\"More on A biotechnological approach for the development of new antifungal compounds to protect the environment and the human health\">Read more<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-4912","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>A biotechnological approach for the development of new antifungal compounds to protect the environment and the human health - Journal of Public Health Research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/613\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A biotechnological approach for the development of new antifungal compounds to protect the environment and the human health - Journal of Public Health Research\" \/>\n<meta property=\"og:description\" content=\"https:\/\/doi.org\/10.4081\/jphr.2015.613 Claudia Zani Department of Medical and Surgical Specialities, Radiological Sciences and Public Health, University of Brescia, Italy. Francesco Maria Restivo Department of Life Sciences, University of Parma, Italy. Mauro Carcelli Department of Chemistry, University of Parma, Italy. Donatella Feretti Department of Medical and Surgical Specialities, Radiological Sciences and Public Health, University of Brescia, Italy. ... 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Francesco Maria Restivo Department of Life Sciences, University of Parma, Italy. Mauro Carcelli Department of Chemistry, University of Parma, Italy. Donatella Feretti Department of Medical and Surgical Specialities, Radiological Sciences and Public Health, University of Brescia, Italy. ... 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