{"id":4794,"date":"2023-03-28T21:44:28","date_gmt":"2023-03-28T19:44:28","guid":{"rendered":"https:\/\/www.jphres.org\/?p=4794"},"modified":"2023-04-02T14:03:49","modified_gmt":"2023-04-02T12:03:49","slug":"clot-characterization-by-multidisciplinary-approach-biochemical-and-imaging-parameters-in-a-hypocoagulative-setting-a-pilot-study","status":"publish","type":"page","link":"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/2358\/","title":{"rendered":"Clot characterization by multidisciplinary approach: biochemical and imaging parameters in a hypocoagulative setting. A pilot study."},"content":{"rendered":"<div class=\"item doi\"><span class=\"value\"><a href=\"https:\/\/doi.org\/10.4081\/jphr.2021.2358\">https:\/\/doi.org\/10.4081\/jphr.2021.2358<\/a><\/span><\/div>\n<ul class=\"item authors\">\n<li><span class=\"name\"><strong>Francesco Marongiu<\/strong><br \/>\n<\/span><span class=\"affiliation\">Hemostasis and Thrombosis Unit, Department of Medical Sciences and Public Health, University of Cagliari, Italy.<\/span><\/li>\n<li><span class=\"name\"><strong>Dimitrios Marco Ntoukas<\/strong><br \/>\n<\/span><span class=\"affiliation\">Hemostasis and Thrombosis Unit, Department of Medical Sciences and Public Health, University of Cagliari, Italy.<\/span><\/li>\n<li><span class=\"name\"><strong>Luigi Barberini<\/strong><br \/>\n<\/span><span class=\"affiliation\">Department of Medical Sciences and Public Health, University of Cagliari, Italy.<\/span><span class=\"orcid\"><a href=\"https:\/\/orcid.org\/0000-0002-3815-0392\" target=\"_blank\" rel=\"noopener\">\u00a0https:\/\/orcid.org\/0000-0002-3815-0392<\/a><\/span><\/li>\n<li><span class=\"name\"><strong>Maria Filomena Ruberto<\/strong><br \/>\n<\/span><span class=\"affiliation\">Hemostasis and Thrombosis Unit, Department of Medical Sciences and Public Health, University of Cagliari, Italy.<\/span><span class=\"orcid\"><a href=\"https:\/\/orcid.org\/0000-0001-9491-1734\" target=\"_blank\" rel=\"noopener\">\u00a0https:\/\/orcid.org\/0000-0001-9491-1734<\/a><\/span><\/li>\n<li><span class=\"name\"><strong>Maria Sebastiana Piras<\/strong><br \/>\n<\/span><span class=\"affiliation\">Hemostasis and Thrombosis Unit, Department of Medical Sciences and Public Health, University of Cagliari, Italy.<\/span><\/li>\n<li><span class=\"name\"><strong>Maria Conti<\/strong><br \/>\n<\/span><span class=\"affiliation\">Liver Unit, Department of Internal Medicine, University Hospital of Cagliari, Italy.<\/span><\/li>\n<li><span class=\"name\"><strong>Maria Luisa Di Martino<\/strong><br \/>\n<\/span><span class=\"affiliation\">Internal Medicine Unit, Department of Medical Sciences and Public Health, University of Cagliari, Italy.<\/span><\/li>\n<li><span class=\"name\"><strong>Mario Mura<\/strong><br \/>\n<\/span><span class=\"affiliation\">Internal Medicine Unit, Department of Medical Sciences and Public Health, University of Cagliari, Italy.<\/span><\/li>\n<li><span class=\"name\"><strong>Silvia Marongiu<\/strong><br \/>\n<\/span><span class=\"affiliation\">Internal Medicine Unit, SS Trinit\u00e0 Hospital, Azienda Tutela della Salute, Cagliari, Italy.<\/span><\/li>\n<li><span class=\"name\"><strong>Maria Luigia Vannini<\/strong><br \/>\n<\/span><span class=\"affiliation\">Hemostasis and Thrombosis Unit, Department of Medical Sciences and Public Health, University of Cagliari, Italy.<\/span><\/li>\n<li><span class=\"name\"><strong>Mattia Lillu<\/strong><br \/>\n<\/span><span class=\"affiliation\">Internal Medicine Unit, Department of Medical Sciences and Public Health, University of Cagliari, Italy.<\/span><\/li>\n<li><span class=\"name\"><strong>Monica Piras<\/strong><br \/>\n<\/span><span class=\"affiliation\">Anatomic-Pathology Unit, Department of Medical Sciences and Public Health, University of Cagliari, Italy.<\/span><\/li>\n<li><span class=\"name\"><strong>Daniela Fanni<\/strong><br \/>\n<\/span><span class=\"affiliation\">Anatomic-Pathology Unit, Department of Medical Sciences and Public Health, University of Cagliari, Italy.<\/span><\/li>\n<li><span class=\"name\"><strong>Lara Fenu<\/strong><br \/>\n<\/span><span class=\"affiliation\">Hemostasis and Thrombosis Unit, Department of Medical Sciences and Public Health, University of Cagliari, Italy.<\/span><\/li>\n<li><strong><span class=\"name\">Carmen Porcu<\/span><\/strong><\/li>\n<li><span class=\"name\"><strong>Doris Barcellona<\/strong><br \/>\n<\/span><span class=\"affiliation\">Hemostasis and Thrombosis Unit, Department of Medical Sciences and Public Health, University of Cagliari, Italy.<\/span><span class=\"orcid\"><a href=\"https:\/\/orcid.org\/0000-0002-0823-3357\" target=\"_blank\" rel=\"noopener\">\u00a0https:\/\/orcid.org\/0000-0002-0823-3357<\/a><\/span><\/li>\n<li><span class=\"name\"><strong>Gavino Faa<\/strong><br \/>\n<\/span><span class=\"affiliation\">SHRO Temple University, Philadelphia, PA, United States.<\/span><\/li>\n<li><span class=\"name\"><strong>Terenzio Congiu<\/strong><br \/>\n<\/span><span class=\"affiliation\">Anatomic-Pathology Unit, Department of Medical Sciences and Public Health, University of Cagliari, Italy.<\/span><\/li>\n<\/ul>\n<div class=\"item abstract\">\n<h3 class=\"label\">ABSTRACT<\/h3>\n<p><strong>Background:\u00a0<\/strong>Clot characterization is, to the present days, a multimodal approach: scanning the clot by electron microscopy (SEM) is helpful for the visualization of fibrin structure along with laboratory parameters such as the clot waveform analysis (CWA) and thrombin generation in different settings of clot abnormalities. This study aimed to assess whether the coagulative parameters were consistent with the clot images texture acquired by SEM, and therefore to propose a more generalist and integrative approach to clots classification.<br \/>\n<strong><br \/>\nDesign and Methods:\u00a0<\/strong>In this pilot study, the examined population consists of eight healthy subjects, seven patients affected by Acquired Hemophilia A (AHA) and seven patients treated with Vitamin K Antagonists (VKAs), similar for age and gender. We studied the velocity and acceleration (1<sup>st<\/sup>\u00a0and 2<sup>nd<\/sup>\u00a0derivative of the aPTT) of clot formation (CWA), the thrombin generation, and the clots&#8217; scanning by SEM. Images acquired with SEM were then analyzed with the MATLAB software with the &#8220;Texture Analysis&#8221; methods to perform classification. Among the various texture parameters, we reported Contrast and Energy.<br \/>\n<strong><br \/>\nResults:\u00a0<\/strong>Significant differences among healthy subjects, patients with AHA and those treated with VKAs were detected for the coagulative parameters. We found no differences between VKAs and AHA patients. Contrast and energy highlighted a significant difference among the three groups in agreement with the laboratory&#8217;s parameters. We found no significant differences between VKAs and AHA patients.<br \/>\n<strong><br \/>\nConclusions:\u00a0<\/strong>The use of SEM, CWA and thrombin generation parameters may be a starting point for studies aimed to demonstrate the general characteristics of clot formation in different clinical conditions with a multiparametric approach.<\/p>\n<div class=\"item author_bios\">\n<h3 class=\"label\">AUTHOR BIOGRAPHIES<\/h3>\n<div class=\"sub_item\">\n<div class=\"label\">Daniela Fanni,\u00a0<span class=\"affiliation\">Anatomic-Pathology Unit, Department of Medical Sciences and Public Health, University of Cagliari<\/span><\/div>\n<div class=\"value\">\n<p>SHRO Temple University, Philadelphia, PA, USA<\/p>\n<\/div>\n<\/div>\n<div class=\"sub_item\">\n<div class=\"label\">Doris Barcellona,\u00a0<span class=\"affiliation\">Hemostasis and Thrombosis Unit, Department of Medical Sciences and Public Health, University of Cagliari<\/span><\/div>\n<div class=\"value\">\n<p>SHRO Temple University, Philadelphia, PA, USA<\/p>\n<\/div>\n<\/div>\n<div class=\"sub_item\">\n<div class=\"label\">Gavino Faa,\u00a0<span class=\"affiliation\">SHRO Temple University, Philadelphia, PA<\/span><\/div>\n<div class=\"value\">\n<p>Anatomic-Pathology Unit, Department of Medical Sciences and Public Health, University of Cagliari, Italy<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"item references\">\n<h3 class=\"label\">REFERENCES<\/h3>\n<div class=\"value\">\n<p>Antoniak S. The coagulation system in host defense. Res Pract Thromb Haemost 2018;2:549-57. DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1002\/rth2.12109\">https:\/\/doi.org\/10.1002\/rth2.12109<\/a><\/p>\n<p>Grover SP, Mackman N. Tissue factor: an essential mediator of hemostasis and trigger of thrombosis. Arterioscler Thromb Vasc Biol 2018;38:709\u201025. DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1161\/ATVBAHA.117.309846\">https:\/\/doi.org\/10.1161\/ATVBAHA.117.309846<\/a><\/p>\n<p>Barcellona D, Marongiu F. The hemostatic system. 1st part. J Pediatr Neonat Individual Med 2020;9:e090106.<\/p>\n<p>Undas A. How to assess fibrinogen levels and fibrin clot properties in clinical practice? Semin Thromb Hemost 2016;42:381-8. DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1055\/s-0036-1579636\">https:\/\/doi.org\/10.1055\/s-0036-1579636<\/a><\/p>\n<p>Z\u0105bczyk M, Undas A. Plasma fibrin clot structure and thromboembolism: clinical implications. Pol Arch Intern Med 2017;127:873-81. DOI:\u00a0<a href=\"https:\/\/doi.org\/10.20452\/pamw.4165\">https:\/\/doi.org\/10.20452\/pamw.4165<\/a><\/p>\n<p>Kessler CM, Kn\u00f6bl P. Acquired haemophilia: an overview for clinical practice. Eur J Haematol 2015;95(S81):36-44. DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1111\/ejh.12689\">https:\/\/doi.org\/10.1111\/ejh.12689<\/a><\/p>\n<p>Ageno W, Gallus AS, Wittkowsky A, et al. Oral anticoagulant therapy: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012;141:e44S-e88S. DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1378\/chest.11-2292\">https:\/\/doi.org\/10.1378\/chest.11-2292<\/a><\/p>\n<p>Hemker HC, Giesen P, Al Dieri R, et al. Calibrated automated thrombin generation measurement in clotting plasma. Pathophysiol Haemost Thromb 2003;33:4-15. DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1159\/000071636\">https:\/\/doi.org\/10.1159\/000071636<\/a><\/p>\n<p>Solano C, Zerafa P, Bird R. A study of atypical APTT derivative curves on the ACL TOP coagulation analyzer. Int J Lab Hematol 2011;33:67-78. DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1111\/j.1751-553X.2010.01248.x\">https:\/\/doi.org\/10.1111\/j.1751-553X.2010.01248.x<\/a><\/p>\n<p>Shima M, Thachil J, Nair SC, Srivastava A. Scientific and standardization committee. towards standardization of clot waveform analysis and recommendations for its clinical applications. J Thromb Haemost 2013;11:1417\u201020. DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1111\/jth.12287\">https:\/\/doi.org\/10.1111\/jth.12287<\/a><\/p>\n<p>MATLAB, 2018. 9.7.0.1190202 (R2019b). Natick: The MathWorks Inc.<\/p>\n<p>Mohanaiah P, Sathyanarayana P, GuruKumar L. Image texture feature extraction using GLCM approach. Intern J Scient Res Pub 2013;3:1-5.<\/p>\n<p>Gonzales RC, Woods RE, Eddins SL. Digital image processing using MATLAB. 3rd ed. Gatesmark Publishing; 2020.<\/p>\n<p>Pieters M, Undas A, Marchi R, et al. An international study on the standardization of fibrin clot permeability measurement: Methodological considerations and implications for healthy control values. J Thromb Haemost 2012;10:2179-81. DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1111\/j.1538-7836.2012.04883.x\">https:\/\/doi.org\/10.1111\/j.1538-7836.2012.04883.x<\/a><\/p>\n<p>Dahlb\u00e4ck B. Blood coagulation. Lancet 2020;355:627-1632. DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(00)02225-X\">https:\/\/doi.org\/10.1016\/S0140-6736(00)02225-X<\/a><\/p>\n<p>Kruse-Jarres R, Kempton CL, Baudo F, et al. Acquired hemophilia A: Updated review of evidence and treatment guidance. Am J Hematol 2017;92:695-705. DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1002\/ajh.24777\">https:\/\/doi.org\/10.1002\/ajh.24777<\/a><\/p>\n<p>Knoebl P, Marco P, Baudo F, et al. Demographic and clinical data in acquired hemophilia A: Results from the European Acquired Haemophilia Registry (EACH2). J Thromb Haemost 2012;10:622-31. DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1111\/j.1538-7836.2012.04654.x\">https:\/\/doi.org\/10.1111\/j.1538-7836.2012.04654.x<\/a><\/p>\n<p>Palareti G, Antonucci E, Migliaccio L, et al. Vitamin K antagonist therapy: Changes in the treated populations and in management results in Italian anticoagulation clinics compared with those recorded 20 years ago. Intern Emerg Med 2017;12:1109-19. DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1007\/s11739-017-1678-9\">https:\/\/doi.org\/10.1007\/s11739-017-1678-9<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>https:\/\/doi.org\/10.4081\/jphr.2021.2358 Francesco Marongiu Hemostasis and Thrombosis Unit, Department of Medical Sciences and Public Health, University of Cagliari, Italy. Dimitrios Marco Ntoukas Hemostasis and Thrombosis Unit, Department of Medical Sciences and Public Health, University of Cagliari, Italy. Luigi Barberini Department of Medical Sciences and Public Health, University of Cagliari, Italy.\u00a0https:\/\/orcid.org\/0000-0002-3815-0392 Maria Filomena Ruberto Hemostasis and Thrombosis &#8230; <a title=\"Clot characterization by multidisciplinary approach: biochemical and imaging parameters in a hypocoagulative setting. A pilot study.\" class=\"read-more\" href=\"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/2358\/\" aria-label=\"More on Clot characterization by multidisciplinary approach: biochemical and imaging parameters in a hypocoagulative setting. A pilot study.\">Read more<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-4794","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Clot characterization by multidisciplinary approach: biochemical and imaging parameters in a hypocoagulative setting. 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Luigi Barberini Department of Medical Sciences and Public Health, University of Cagliari, Italy.\u00a0https:\/\/orcid.org\/0000-0002-3815-0392 Maria Filomena Ruberto Hemostasis and Thrombosis ... Read more","og_url":"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/2358\/","og_site_name":"Journal of Public Health Research","article_modified_time":"2023-04-02T12:03:49+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/2358\/","url":"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/2358\/","name":"Clot characterization by multidisciplinary approach: biochemical and imaging parameters in a hypocoagulative setting. 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