{"id":4756,"date":"2023-03-29T07:27:38","date_gmt":"2023-03-29T05:27:38","guid":{"rendered":"https:\/\/www.jphres.org\/?p=4756"},"modified":"2023-04-02T14:00:13","modified_gmt":"2023-04-02T12:00:13","slug":"high-fructose-diet-initially-promotes-increased-aortic-wall-thickness-liver-steatosis-and-cardiac-histopathology-deterioration-but-does-not-increase-body-fat-index","status":"publish","type":"page","link":"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/2181\/","title":{"rendered":"High-fructose diet initially promotes increased aortic wall thickness, liver steatosis, and cardiac histopathology deterioration, but does not increase body fat index"},"content":{"rendered":"<div class=\"item doi\"><span class=\"value\"><a href=\"https:\/\/doi.org\/10.4081\/jphr.2021.2181\">https:\/\/doi.org\/10.4081\/jphr.2021.2181<\/a><\/span><\/div>\n<ul class=\"item authors\">\n<li><span class=\"name\"><strong>Dian Handayani<\/strong><br \/>\n<span class=\"affiliation\">Department of Nutrition, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.<\/span><span class=\"orcid\"><br \/>\n<a href=\"https:\/\/orcid.org\/0000-0002-3117-9723\" target=\"_blank\" rel=\"noopener\">https:\/\/orcid.org\/0000-0002-3117-9723<\/a><\/span><\/span><\/li>\n<li><span class=\"name\"><strong>Erlinda Febrianingsih<\/strong><br \/>\n<\/span><span class=\"affiliation\">Department of Nutrition, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.<\/span><\/li>\n<li><span class=\"name\"><strong>Adelya Desi Kurniawati<\/strong><br \/>\n<\/span><span class=\"affiliation\">Department of Nutrition, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.<br \/>\n<\/span><span class=\"orcid\"><a href=\"https:\/\/orcid.org\/0000-0002-3344-8552\" target=\"_blank\" rel=\"noopener\">https:\/\/orcid.org\/0000-0002-3344-8552<\/a><\/span><\/li>\n<li><span class=\"name\"><strong>Inggita Kusumastuty<\/strong><br \/>\n<\/span><span class=\"affiliation\">Department of Nutrition, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.<\/span><span class=\"orcid\"><br \/>\n<a href=\"https:\/\/orcid.org\/0000-0002-0481-4541\" target=\"_blank\" rel=\"noopener\">https:\/\/orcid.org\/0000-0002-0481-4541<\/a><\/span><\/li>\n<li><span class=\"name\"><strong>Shafira Nurmalitasari<\/strong><br \/>\n<\/span><span class=\"affiliation\">Department of Nutrition, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.<br \/>\n<\/span><span class=\"orcid\"><a href=\"https:\/\/orcid.org\/0000-0002-7591-0338\" target=\"_blank\" rel=\"noopener\">https:\/\/orcid.org\/0000-0002-7591-0338<\/a><\/span><\/li>\n<li><span class=\"name\"><strong>Rahma Micho Widyanto<\/strong><br \/>\n<\/span><span class=\"affiliation\">Department of Nutrition, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.<\/span><span class=\"orcid\"><br \/>\n<a href=\"https:\/\/orcid.org\/0000-0003-4934-8131\" target=\"_blank\" rel=\"noopener\">https:\/\/orcid.org\/0000-0003-4934-8131<\/a><\/span><\/li>\n<li><span class=\"name\"><strong>Diah Novida Oktaviani<\/strong><br \/>\n<\/span><span class=\"affiliation\">Department of Nutrition, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.<\/span><\/li>\n<li><span class=\"name\"><strong>Alma Maghfirotun Innayah<\/strong><br \/>\n<\/span><span class=\"affiliation\">Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.<\/span><\/li>\n<li><span class=\"name\"><strong>Etik Sulistyowati<\/strong><br \/>\n<\/span><span class=\"affiliation\">Nutrition Department, Polytechnic of Health, Malang, Indonesia.<\/span><span class=\"orcid\"><br \/>\n<a href=\"https:\/\/orcid.org\/0000-0003-0351-9871\" target=\"_blank\" rel=\"noopener\">https:\/\/orcid.org\/0000-0003-0351-9871<\/a><\/span><\/li>\n<\/ul>\n<div class=\"item abstract\">\n<h3 class=\"label\">ABSTRACT<\/h3>\n<p><em>Background:\u00a0<\/em>Dietary fats and fructose have been responsible for inducing obesity and body tissues damage due to the consequence of metabolic syndrome through several mechanisms. The body fat index (BFI) is one of the anthropometric measures used to detect obesity in rats. This study aims to examine the correlation between high-fat high-fructose diet and liver steatosis cell count, early atherosclerosis characteristics, and BFI in Sprague Dawley Rats.<br \/>\n<em><br \/>\nDesign and methods:\u00a0<\/em>This was an experimental design using 2 groups of 12-weeks-old Sprague Dawley (SD) rats. The control group received a standard diet and tap water beverages for 17 weeks. The intervention group was fed with high-fat diet from modified AIN 93-M and additional 30% fructose drink. We analyzed the foam cell count, aortic wall thickness, cardiac histopathology, and liver steatosis cell count after the sacrifice process.<br \/>\n<em><br \/>\nResults:\u00a0<\/em>The rats in the intervention group had a higher aortic wall thickness, liver steatosis, and foam cell count (+125%, p&lt;0.01; +317%, p&lt;0.01 and +165%, p&lt;0.01 respectively) compared to the control group. The intervention group also showed higher mononuclear inflammatory and hypertrophic cell count. A significant positive correlation was found between dietary fructose with premature atherosclerosis by increasing foam cell count (r=0.66) and aortic wall thickness (r=0.68). In addition, 30% dietary fructose increased liver steatosis (r =0.69) and mononuclear inflammatory cardiac cell count (r=0.61). Interestingly, the intervention had no effect on BFI (p&gt;0.5; r=0.13).<br \/>\n<em><br \/>\nConclusions:\u00a0<\/em>Dietary fat and fructose consumption for 17 weeks promote atherosclerosis, liver steatosis, and cardiac histopathology alteration without increasing BFI.<\/p>\n<h3 class=\"label\">REFERENCES<\/h3>\n<div class=\"value\">\n<p>Suzuki K, Jayasena CN, Bloom SR. Obesity and appetite control. Exp Diabetes Res 2012;2012:1\u20139. DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1155\/2012\/824305\">https:\/\/doi.org\/10.1155\/2012\/824305<\/a><\/p>\n<p>Sladoje DP, Kisi\u0107 B, Miri\u0107 D. 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Adelya Desi Kurniawati Department of Nutrition, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia. https:\/\/orcid.org\/0000-0002-3344-8552 Inggita Kusumastuty Department of Nutrition, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia. https:\/\/orcid.org\/0000-0002-0481-4541 Shafira Nurmalitasari &#8230; <a title=\"High-fructose diet initially promotes increased aortic wall thickness, liver steatosis, and cardiac histopathology deterioration, but does not increase body fat index\" class=\"read-more\" href=\"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/2181\/\" aria-label=\"More on High-fructose diet initially promotes increased aortic wall thickness, liver steatosis, and cardiac histopathology deterioration, but does not increase body fat index\">Read more<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-4756","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>High-fructose diet initially promotes increased aortic wall thickness, liver steatosis, and cardiac histopathology deterioration, but does not increase body fat index - Journal of Public Health Research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/2181\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"High-fructose diet initially promotes increased aortic wall thickness, liver steatosis, and cardiac histopathology deterioration, but does not increase body fat index - Journal of Public Health Research\" \/>\n<meta property=\"og:description\" content=\"https:\/\/doi.org\/10.4081\/jphr.2021.2181 Dian Handayani Department of Nutrition, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia. https:\/\/orcid.org\/0000-0002-3117-9723 Erlinda Febrianingsih Department of Nutrition, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia. Adelya Desi Kurniawati Department of Nutrition, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia. https:\/\/orcid.org\/0000-0002-3344-8552 Inggita Kusumastuty Department of Nutrition, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia. https:\/\/orcid.org\/0000-0002-0481-4541 Shafira Nurmalitasari ... 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Adelya Desi Kurniawati Department of Nutrition, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia. https:\/\/orcid.org\/0000-0002-3344-8552 Inggita Kusumastuty Department of Nutrition, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia. https:\/\/orcid.org\/0000-0002-0481-4541 Shafira Nurmalitasari ... 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