{"id":4655,"date":"2023-03-28T16:55:36","date_gmt":"2023-03-28T14:55:36","guid":{"rendered":"https:\/\/www.jphres.org\/?p=4655"},"modified":"2023-04-02T14:05:49","modified_gmt":"2023-04-02T12:05:49","slug":"in-utero-exposure-to-endocrine-disrupting-chemicals-micro-rna-profiles-and-fetal-growth-a-pilot-study-protocol","status":"publish","type":"page","link":"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/1550\/","title":{"rendered":"In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol"},"content":{"rendered":"<div class=\"item doi\"><span class=\"value\"><a href=\"https:\/\/doi.org\/10.4081\/jphr.2019.1550\">https:\/\/doi.org\/10.4081\/jphr.2019.1550<\/a><\/span><\/div>\n<ul class=\"item authors\">\n<li><span class=\"name\"><strong>Tricia L. Larose<\/strong><br \/>\nK.G. Jebsen Center for Genetic Epidemiology, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.<\/span><\/li>\n<li><strong><span class=\"name\">P\u00e5l S\u00e6trom<\/span><\/strong><span class=\"affiliation\"><strong>1<\/strong><br \/>\nK.G. Jebsen Center for Genetic Epidemiology, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Department of Computer Science, Faculty of Information Technology and Electrical Engineering, Norwegian University of Science and Technology, Trondheim; Bioinformatics core facility \u2013 BioCore, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.<\/span><\/li>\n<li><span class=\"name\"><strong>Marit P. Martinussen<\/strong><br \/>\n<\/span><span class=\"affiliation\">Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.<\/span><\/li>\n<li><span class=\"name\"><strong>H\u00e5kon Skogseth<\/strong><br \/>\n<\/span><span class=\"affiliation\">Biobank 1, St. Olavs University Hospital, Trondheim, Norway.<\/span><\/li>\n<li><span class=\"name\"><strong>Torkjel M. Sandanger<\/strong><br \/>\n<\/span><span class=\"affiliation\">Department of Community Medicine, Faculty of Health Sciences, UiT-the Arctic University of Norway, Troms\u00f8, Norway.<\/span><\/li>\n<li><span class=\"name\"><strong>Ghislaine Scelo<\/strong><br \/>\n<\/span><span class=\"affiliation\">Genetic Epidemiology Group, Section of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France.<\/span><\/li>\n<li><span class=\"name\"><strong>Cliona M. McHale<\/strong><br \/>\n<\/span><span class=\"affiliation\">Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, United States.<\/span><\/li>\n<li><span class=\"name\"><strong>Geir W. Jacobsen<\/strong><br \/>\n<\/span><span class=\"affiliation\">Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.<\/span><\/li>\n<li><span class=\"name\"><strong>Martyn T. Smith<\/strong><br \/>\n<\/span><span class=\"affiliation\">Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, United States.<\/span><\/li>\n<\/ul>\n<div class=\"item abstract\">\n<h3 class=\"label\">ABSTRACT<\/h3>\n<p><em>Background:<\/em>\u00a0The developing fetus is particularly vulnerable to the effects of endocrine disrupting chemicals (EDCs). Molecular fingerprints of EDCs can be identified via microRNA (miRNA) expression profiles and may be etiologically implicated in the developmental origin of disease (DOHaD).<br \/>\n<em><br \/>\nMethods\/design<\/em>: This pilot study includes pregnant women at high risk (smoking at conception), and low risk (non-smoking at conception) for SGA birth (birthweight&lt;10th percentile for gestational age). We have randomly selected 12 mothers (3 high-risk SGA birth, 3 low-risk SGA birth, 3 high-risk non-SGA birth, 3 low-risk non-SGA birth), with EDC measurements from gestational week 17. All offspring are female. We aim to test the stability of our samples (maternal serum, cord blood, placenta tissue), observe the differential expression of miRNA profiles over time (gestational weeks 17, 25, 33, 37, birth), and study the consistency between maternal EDC measures and miRNA expression profiles across our repeated measures.<br \/>\n<em><br \/>\nExpected impact of the study for Public Health:<\/em>\u00a0Results from this pilot study will inform the development of a larger cohort wide analysis, and will impact the current state of knowledge in the fields of public health, epigenetics, and the DOHaD.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>https:\/\/doi.org\/10.4081\/jphr.2019.1550 Tricia L. Larose K.G. Jebsen Center for Genetic Epidemiology, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. P\u00e5l S\u00e6trom1 K.G. Jebsen Center for Genetic Epidemiology, Faculty of Medicine and &#8230; <a title=\"In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol\" class=\"read-more\" href=\"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/1550\/\" aria-label=\"More on In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol\">Read more<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-4655","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol - Journal of Public Health Research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/1550\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol - Journal of Public Health Research\" \/>\n<meta property=\"og:description\" content=\"https:\/\/doi.org\/10.4081\/jphr.2019.1550 Tricia L. Larose K.G. Jebsen Center for Genetic Epidemiology, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. P\u00e5l S\u00e6trom1 K.G. Jebsen Center for Genetic Epidemiology, Faculty of Medicine and ... Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/1550\/\" \/>\n<meta property=\"og:site_name\" content=\"Journal of Public Health Research\" \/>\n<meta property=\"article:modified_time\" content=\"2023-04-02T12:05:49+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/1550\/\",\"url\":\"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/1550\/\",\"name\":\"In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol - Journal of Public Health Research\",\"isPartOf\":{\"@id\":\"https:\/\/www.jphres.us.com\/#website\"},\"datePublished\":\"2023-03-28T14:55:36+00:00\",\"dateModified\":\"2023-04-02T12:05:49+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/1550\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/1550\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/1550\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Startseite\",\"item\":\"https:\/\/www.jphres.us.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.jphres.us.com\/#website\",\"url\":\"https:\/\/www.jphres.us.com\/\",\"name\":\"Journal of Public Health Research\",\"description\":\"The Journal of Public Health Research is an online Open Access, peer-reviewed journal in the field of public health science. The scope of the journal is to stimulate debate and spreading of knowledge in this area in order to improve public health.\",\"publisher\":{\"@id\":\"https:\/\/www.jphres.us.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.jphres.us.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.jphres.us.com\/#organization\",\"name\":\"Journal of Public Health Research\",\"url\":\"https:\/\/www.jphres.us.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.jphres.us.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.jphres.us.com\/wp-content\/uploads\/2022\/10\/Favicon-JPHRES.png\",\"contentUrl\":\"https:\/\/www.jphres.us.com\/wp-content\/uploads\/2022\/10\/Favicon-JPHRES.png\",\"width\":150,\"height\":114,\"caption\":\"Journal of Public Health Research\"},\"image\":{\"@id\":\"https:\/\/www.jphres.us.com\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.citefactor.org\/journal\/index\/5410\/journal-of-public-health-research#.ZD-hS-xBx3k\",\"https:\/\/www.scimagojr.com\/journalsearch.php?q=21100790524&amp;amp;tip=sid&amp;amp;clean=0\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol - Journal of Public Health Research","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/1550\/","og_locale":"en_US","og_type":"article","og_title":"In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol - Journal of Public Health Research","og_description":"https:\/\/doi.org\/10.4081\/jphr.2019.1550 Tricia L. Larose K.G. Jebsen Center for Genetic Epidemiology, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. P\u00e5l S\u00e6trom1 K.G. Jebsen Center for Genetic Epidemiology, Faculty of Medicine and ... Read more","og_url":"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/1550\/","og_site_name":"Journal of Public Health Research","article_modified_time":"2023-04-02T12:05:49+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/1550\/","url":"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/1550\/","name":"In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol - Journal of Public Health Research","isPartOf":{"@id":"https:\/\/www.jphres.us.com\/#website"},"datePublished":"2023-03-28T14:55:36+00:00","dateModified":"2023-04-02T12:05:49+00:00","breadcrumb":{"@id":"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/1550\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/1550\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/1550\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Startseite","item":"https:\/\/www.jphres.us.com\/"},{"@type":"ListItem","position":2,"name":"In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol"}]},{"@type":"WebSite","@id":"https:\/\/www.jphres.us.com\/#website","url":"https:\/\/www.jphres.us.com\/","name":"Journal of Public Health Research","description":"The Journal of Public Health Research is an online Open Access, peer-reviewed journal in the field of public health science. The scope of the journal is to stimulate debate and spreading of knowledge in this area in order to improve public health.","publisher":{"@id":"https:\/\/www.jphres.us.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.jphres.us.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.jphres.us.com\/#organization","name":"Journal of Public Health Research","url":"https:\/\/www.jphres.us.com\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.jphres.us.com\/#\/schema\/logo\/image\/","url":"https:\/\/www.jphres.us.com\/wp-content\/uploads\/2022\/10\/Favicon-JPHRES.png","contentUrl":"https:\/\/www.jphres.us.com\/wp-content\/uploads\/2022\/10\/Favicon-JPHRES.png","width":150,"height":114,"caption":"Journal of Public Health Research"},"image":{"@id":"https:\/\/www.jphres.us.com\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.citefactor.org\/journal\/index\/5410\/journal-of-public-health-research#.ZD-hS-xBx3k","https:\/\/www.scimagojr.com\/journalsearch.php?q=21100790524&amp;amp;tip=sid&amp;amp;clean=0"]}]}},"_links":{"self":[{"href":"https:\/\/www.jphres.us.com\/index.php\/wp-json\/wp\/v2\/pages\/4655","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jphres.us.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.jphres.us.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.jphres.us.com\/index.php\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jphres.us.com\/index.php\/wp-json\/wp\/v2\/comments?post=4655"}],"version-history":[{"count":0,"href":"https:\/\/www.jphres.us.com\/index.php\/wp-json\/wp\/v2\/pages\/4655\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.jphres.us.com\/index.php\/wp-json\/wp\/v2\/media?parent=4655"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}