{"id":4590,"date":"2023-03-28T09:51:44","date_gmt":"2023-03-28T07:51:44","guid":{"rendered":"https:\/\/www.jphres.org\/?p=4590"},"modified":"2023-04-02T14:08:22","modified_gmt":"2023-04-02T12:08:22","slug":"trends-in-5-10-20-and-30-year-survival-rates-of-beta-thalassemia-patients-in-southern-iran-1995-2016-a-retrospective-cohort-study","status":"publish","type":"page","link":"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/1001\/","title":{"rendered":"Trends in 5-, 10-, 20-, and 30-year survival rates of beta-thalassemia patients in Southern Iran, 1995-2016: A retrospective cohort study"},"content":{"rendered":"<div class=\"item doi\"><span class=\"value\"><a href=\"https:\/\/doi.org\/10.4081\/jphr.2017.1001\">https:\/\/doi.org\/10.4081\/jphr.2017.1001<\/a><\/span><\/div>\n<ul class=\"item authors\">\n<li><span class=\"name\"><strong>Jafar Hassanzadeh<\/strong><br \/>\n<\/span><span class=\"affiliation\">Research Centre for Health Sciences, Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Iran, Islamic Republic of.<\/span><\/li>\n<li><span class=\"name\"><strong>Alireza Mirahmadizadeh<\/strong><br \/>\n<\/span><span class=\"affiliation\">Department of Epidemiology, School of Health, Non-Communicable Diseases Research Center, Shiraz University of Medical Sciences, Iran, Islamic Republic of.<\/span><\/li>\n<li><span class=\"name\"><strong>Mehran Karimi<\/strong><br \/>\n<\/span><span class=\"affiliation\">Hematology Research Center, Shiraz University of Medical Sciences, Iran, Islamic Republic of.<\/span><\/li>\n<li><span class=\"name\"><strong>Yousef Veisani<\/strong><br \/>\n<\/span><span class=\"affiliation\">Psychosocial Injuries Research Center, Ilam University of Medical Sciences, Iran, Islamic Republic of.<\/span><\/li>\n<li><span class=\"name\"><strong>Shahab Rezaeian<\/strong><br \/>\n<span class=\"affiliation\">Research Center for Environmental Determinants of Health, Kermanshah University of Medical Sciences, Kermanshah; Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Iran, Islamic Republic of.<\/span><span class=\"orcid\"><br \/>\n<a href=\"http:\/\/orcid.org\/0000-0002-5094-5315\" target=\"_blank\" rel=\"noopener\">http:\/\/orcid.org\/0000-0002-5094-5315<\/a><\/span><\/span><\/li>\n<\/ul>\n<div class=\"item abstract\">\n<h3 class=\"label\">ABSTRACT<\/h3>\n<p><em>Background<\/em>: There is currently lack of knowledge about survival trend analysis of thalassemia patients. Therefore, the aim of the present study was to assess 5-, 10-, 20-, and 30-year survival of thalassemia patients over a 20-year time period.<br \/>\n<em>Methods<\/em>: In this retrospective cohort study, we analysed the data of 982 beta-thalassemia patients in Iran. Birth cohort and traditional cohort analyses were used to obtain the 5-, 10-, 20-, and 30-year survival rates in various time intervals between 1995 and 2016.<br \/>\n<em>Results<\/em>: Five and 10-year survival rates remained unchanged since 1995-2016. Overall, 20- and 30-year survival rates were lower in younger birth cohorts than older ones. A declining trend was found in 20-year survival rate from 1995 to 2000 for all and also for thalassemia major patients, but was stable from 2001 to 2016. In addition, there was a declining trend in 30-year survival rate from 1995 to 2008 for all and also for thalassemia major patients, but was an increased trend from 2009 to 2016.<br \/>\n<em>Conclusion<\/em>: Over the past two decades and in recent birth cohorts, the 20- and 30-year survival rates has declined. In other words, declining survival trends in the birth cohorts may be associated with some different causes of mortality such as exposure to the toxic effects of iron over time and the occurrence of diseaserelated mortality.<\/p>\n<\/div>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>https:\/\/doi.org\/10.4081\/jphr.2017.1001 Jafar Hassanzadeh Research Centre for Health Sciences, Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Iran, Islamic Republic of. Alireza Mirahmadizadeh Department of Epidemiology, School of Health, Non-Communicable Diseases Research Center, Shiraz University of Medical Sciences, Iran, Islamic Republic of. Mehran Karimi Hematology Research Center, Shiraz University of Medical Sciences, Iran, &#8230; <a title=\"Trends in 5-, 10-, 20-, and 30-year survival rates of beta-thalassemia patients in Southern Iran, 1995-2016: A retrospective cohort study\" class=\"read-more\" href=\"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/1001\/\" aria-label=\"More on Trends in 5-, 10-, 20-, and 30-year survival rates of beta-thalassemia patients in Southern Iran, 1995-2016: A retrospective cohort study\">Read more<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-4590","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Trends in 5-, 10-, 20-, and 30-year survival rates of beta-thalassemia patients in Southern Iran, 1995-2016: A retrospective cohort study - Journal of Public Health Research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/1001\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Trends in 5-, 10-, 20-, and 30-year survival rates of beta-thalassemia patients in Southern Iran, 1995-2016: A retrospective cohort study - Journal of Public Health Research\" \/>\n<meta property=\"og:description\" content=\"https:\/\/doi.org\/10.4081\/jphr.2017.1001 Jafar Hassanzadeh Research Centre for Health Sciences, Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Iran, Islamic Republic of. Alireza Mirahmadizadeh Department of Epidemiology, School of Health, Non-Communicable Diseases Research Center, Shiraz University of Medical Sciences, Iran, Islamic Republic of. Mehran Karimi Hematology Research Center, Shiraz University of Medical Sciences, Iran, ... 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Alireza Mirahmadizadeh Department of Epidemiology, School of Health, Non-Communicable Diseases Research Center, Shiraz University of Medical Sciences, Iran, Islamic Republic of. Mehran Karimi Hematology Research Center, Shiraz University of Medical Sciences, Iran, ... 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