{"id":4545,"date":"2023-03-29T13:56:44","date_gmt":"2023-03-29T11:56:44","guid":{"rendered":"https:\/\/www.jphres.org\/?p=4545"},"modified":"2023-04-02T13:56:53","modified_gmt":"2023-04-02T11:56:53","slug":"review-of-medicine-utilization-for-parkinsons-disease-management-the-bulgarian-perspective","status":"publish","type":"page","link":"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/2396\/","title":{"rendered":"Review of medicine utilization for Parkinson\u2019s disease management: the Bulgarian perspective"},"content":{"rendered":"<div class=\"item doi\"><span class=\"value\"><a href=\"https:\/\/doi.org\/10.4081\/jphr.2021.2396\">https:\/\/doi.org\/10.4081\/jphr.2021.2396<\/a><\/span><\/div>\n<ul class=\"item authors\">\n<li><span class=\"name\"><strong>Zornitsa Mitkova<\/strong><br \/>\n<span class=\"affiliation\">Department of Organisation and Economy of Pharmacy, Faculty of Pharmacy, Medical University of Sofia, Bulgaria.<\/span><span class=\"orcid\"><br \/>\n<a href=\"https:\/\/orcid.org\/0000-0003-0782-200X\" target=\"_blank\" rel=\"noopener\">https:\/\/orcid.org\/0000-0003-0782-200X<\/a><\/span><\/span><\/li>\n<li><span class=\"name\"><strong>Maria Kamusheva<\/strong><br \/>\n<\/span><span class=\"affiliation\">Department of Organisation and Economy of Pharmacy, Faculty of Pharmacy, Medical University of Sofia, Bulgaria.<\/span><\/li>\n<li><span class=\"name\"><strong>Dobrinka Kalpachka<\/strong><br \/>\n<\/span><span class=\"affiliation\">Department of Neurology, \u201cSaint Anna\u201d Hospital, Sofia , Bulgaria.<\/span><\/li>\n<li><span class=\"name\"><strong>Desislava Ignatova<\/strong><br \/>\n<\/span><span class=\"affiliation\">Department of Psychiatry and Medical Psychology, Medical University of Sofia, Bulgaria.<\/span><span class=\"orcid\"><br \/>\n<a href=\"https:\/\/orcid.org\/0000-0002-1645-6366\" target=\"_blank\" rel=\"noopener\">https:\/\/orcid.org\/0000-0002-1645-6366<\/a><\/span><\/li>\n<li><span class=\"name\"><strong>Konstantin Tachkov<\/strong><br \/>\n<\/span><span class=\"affiliation\">Department of Organisation and Economy of Pharmacy, Faculty of Pharmacy, Medical University of Sofia, Bulgaria.<\/span><\/li>\n<li><span class=\"name\"><strong>Guenka Petrova<\/strong><br \/>\n<\/span><span class=\"affiliation\">Department of Organisation and Economy of Pharmacy, Faculty of Pharmacy, Medical University of Sofia, Bulgaria.<\/span><\/li>\n<\/ul>\n<div class=\"item abstract\">\n<h3 class=\"label\">ABSTRACT<\/h3>\n<p><em>Background:\u00a0<\/em>Parkinson\u2019s disease (PD), which occurs in 1% of the population, is the second most common neurodegenerative disorder. Despite the broad spectrum of PD manifestations and high disease prevalence, there are insufficient data on medicine utilization and prescription strategies. The purpose of the current study was to analyze published data concerning treatment approaches and to compare them with Bulgarian therapeutic practice.<br \/>\n<em><br \/>\nDesign and methods:\u00a0<\/em>We conducted a systematic review of the PubMed and Google Scholar databases, and we calculated medicine utilization in Bulgaria during 2018 and 2019 using the WHO methodology.<br \/>\n<em><br \/>\nResults:\u00a0<\/em>The literature search identified a total of 311 publications, but only 12 met the inclusion criteria. Eleven studies pointed out that levodopa-containing medicine are the most frequently used, followed by dopamine agonists. The highest rate was found for levodopa-containing products and decarboxylase inhibitor (1.06 and 1.33 DDD\/1000 inh\/day), followed by anticholinergic Biperiden (0.494 and 0.455 DDD\/1000 inh\/day) during 2018 and 2019 in Bulgaria.<br \/>\n<em><br \/>\nConclusion:\u00a0<\/em>Overall, the treatment approaches used in the last decade comply with guideline recommendations, despite variations in levodopa and dopamine agonist utilization. Even though new medicines have been approved for PD management, levodopa-containing products are still most often prescribed and used worldwide.<\/p>\n<h3 class=\"label\">REFERENCES<\/h3>\n<div class=\"value\">\n<p>Parkinson\u2019s Disease Collaborators. Global, regional, and national burden of Parkinson&#8217;s disease, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 2018;17:939-53. 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DOI:\u00a0<a href=\"https:\/\/doi.org\/10.3390\/brainsci10120925\">https:\/\/doi.org\/10.3390\/brainsci10120925<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>https:\/\/doi.org\/10.4081\/jphr.2021.2396 Zornitsa Mitkova Department of Organisation and Economy of Pharmacy, Faculty of Pharmacy, Medical University of Sofia, Bulgaria. https:\/\/orcid.org\/0000-0003-0782-200X Maria Kamusheva Department of Organisation and Economy of Pharmacy, Faculty of Pharmacy, Medical University of Sofia, Bulgaria. Dobrinka Kalpachka Department of Neurology, \u201cSaint Anna\u201d Hospital, Sofia , Bulgaria. Desislava Ignatova Department of Psychiatry and Medical Psychology, &#8230; <a title=\"Review of medicine utilization for Parkinson\u2019s disease management: the Bulgarian perspective\" class=\"read-more\" href=\"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/2396\/\" aria-label=\"More on Review of medicine utilization for Parkinson\u2019s disease management: the Bulgarian perspective\">Read more<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-4545","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Review of medicine utilization for Parkinson\u2019s disease management: the Bulgarian perspective - Journal of Public Health Research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/2396\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Review of medicine utilization for Parkinson\u2019s disease management: the Bulgarian perspective - Journal of Public Health Research\" \/>\n<meta property=\"og:description\" content=\"https:\/\/doi.org\/10.4081\/jphr.2021.2396 Zornitsa Mitkova Department of Organisation and Economy of Pharmacy, Faculty of Pharmacy, Medical University of Sofia, Bulgaria. https:\/\/orcid.org\/0000-0003-0782-200X Maria Kamusheva Department of Organisation and Economy of Pharmacy, Faculty of Pharmacy, Medical University of Sofia, Bulgaria. Dobrinka Kalpachka Department of Neurology, \u201cSaint Anna\u201d Hospital, Sofia , Bulgaria. Desislava Ignatova Department of Psychiatry and Medical Psychology, ... 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Dobrinka Kalpachka Department of Neurology, \u201cSaint Anna\u201d Hospital, Sofia , Bulgaria. Desislava Ignatova Department of Psychiatry and Medical Psychology, ... 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