{"id":4444,"date":"2023-03-27T04:54:43","date_gmt":"2023-03-27T02:54:43","guid":{"rendered":"https:\/\/www.jphres.org\/?p=4444"},"modified":"2023-04-02T14:18:41","modified_gmt":"2023-04-02T12:18:41","slug":"the-effect-of-rhodamine-b-on-the-cerebellum-and-brainstem-tissue-of-rattus-norvegicus","status":"publish","type":"page","link":"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/1812\/","title":{"rendered":"The effect of Rhodamine B on the cerebellum and brainstem tissue of Rattus norvegicus"},"content":{"rendered":"<div class=\"item doi\"><span class=\"value\"><a href=\"https:\/\/doi.org\/10.4081\/jphr.2020.1812\">https:\/\/doi.org\/10.4081\/jphr.2020.1812<\/a><\/span><\/div>\n<ul class=\"item authors\">\n<li><span class=\"name\"><strong>Dewi Ratna Sulistina<\/strong><br \/>\n<\/span><span class=\"affiliation\">Doctoral Program of Public Health, Faculty of Public Health, Universitas Airlangga, Mulyorejo, Surabaya, Indonesia.<\/span><\/li>\n<li><span class=\"name\"><strong>Santi Martini<\/strong><br \/>\nDepartment of Epidemiology, Faculty of Public Health, Universitas Airlangga, Mulyorejo, Surabaya,, Indonesia.<\/span><\/li>\n<\/ul>\n<div class=\"item abstract\">\n<h3 class=\"label\">ABSTRACT<\/h3>\n<p>Background: Rhodamine B is a component of xenobiotic substance metabolized by cytochrome P450 in the body to produce free radicals, which affects the activity of Superoxidase Dismutase (SOD), thereby, leading to oxidative stress, injury, increase in cell apoptosis and brainstem. This study aims to determine the effect of Rhodamine B on BAX and BCL-2 in the cerebellum and brainstem tissue of\u00a0<em>Rattus<\/em>\u00a0<em>norvegicus<\/em>.<br \/>\nDesign and Methods: The True Experimental Design was used to carry out a post-test examination on the control group of twenty-eight Wistar female\u00a0<em>Rattus norvegicus<\/em>\u00a0mice between the ages of 10-12 weeks. Then, samples were categorized into 4 groups in body weight doses of 4.5 mg\/200g, 9 mg\/200g, and 18 mg\/200g. They were administrated with Rhodamine B personde for 36 days.<br \/>\nResults: The results showed that Rhodamine B had a direct and indirect effect on BAX and BCL-2 expressions, respectively, in the cerebellum tissue and wistar strain of Rattus norvegicus. In addition, the positive path coefficient of BAX expression has a positive effect on BCL-2. This means that an increase in BAX has a direct impact on decreasing BCL-2 expression in cerebellum tissue and brainstem of Rattus norvegicus wistar strain along with an increased dose of Rhodamine B.<br \/>\nConclusions: In conclusion, Rhodamine B tends to increase BAX expression which directly decreases BCL-2 in Cerebellum tissue and Brainstem in Rattus norvegicus along with increasing doses.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>https:\/\/doi.org\/10.4081\/jphr.2020.1812 Dewi Ratna Sulistina Doctoral Program of Public Health, Faculty of Public Health, Universitas Airlangga, Mulyorejo, Surabaya, Indonesia. Santi Martini Department of Epidemiology, Faculty of Public Health, Universitas Airlangga, Mulyorejo, Surabaya,, Indonesia. ABSTRACT Background: Rhodamine B is a component of xenobiotic substance metabolized by cytochrome P450 in the body to produce free radicals, which affects &#8230; <a title=\"The effect of Rhodamine B on the cerebellum and brainstem tissue of Rattus norvegicus\" class=\"read-more\" href=\"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/1812\/\" aria-label=\"More on The effect of Rhodamine B on the cerebellum and brainstem tissue of Rattus norvegicus\">Read more<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-4444","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The effect of Rhodamine B on the cerebellum and brainstem tissue of Rattus norvegicus - Journal of Public Health Research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.jphres.us.com\/index.php\/jphres\/article\/view\/1812\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The effect of Rhodamine B on the cerebellum and brainstem tissue of Rattus norvegicus - Journal of Public Health Research\" \/>\n<meta property=\"og:description\" content=\"https:\/\/doi.org\/10.4081\/jphr.2020.1812 Dewi Ratna Sulistina Doctoral Program of Public Health, Faculty of Public Health, Universitas Airlangga, Mulyorejo, Surabaya, Indonesia. Santi Martini Department of Epidemiology, Faculty of Public Health, Universitas Airlangga, Mulyorejo, Surabaya,, Indonesia. ABSTRACT Background: Rhodamine B is a component of xenobiotic substance metabolized by cytochrome P450 in the body to produce free radicals, which affects ... 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